ABCC8 gene variant and efficacy of gliclazide Ser1369Ala variant in sulphonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients
نویسندگان
چکیده
1. Anhui Biomedical Institute, Anhui Medical University, Hefei, China 2. Division of Endocrinology, the Second Hospital, Harbin Medical University, Harbin, China 3. Division of Endocrinology, the First Hospital, Harbin Medical University, Harbin, China 4. Tianjin Medical University Metabolic Hospital, Tianjin, China 5. Division of Endocrinology, Tongren Hospital, Capital Medical University, Beijing, China 6. Division of Endocrinology, the First Hefei People Hospital, Hefei, China 7. The Mary Ann and J. Milburn Smith Child Health Research Program, Children’s Memorial Hospital and Children’s Memorial Research Center, Chicago, IL USA;
منابع مشابه
Ser1369Ala Variant in Sulfonylurea Receptor Gene ABCC8 Is Associated With Antidiabetic Efficacy of Gliclazide in Chinese Type 2 Diabetic Patients
OBJECTIVE The purpose of this study was to investigate whether genetic variants could influence the antidiabetic efficacy of gliclazide in type 2 diabetic patients. RESEARCH DESIGN AND METHODS A total of 1,268 type 2 diabetic patients whose diabetes was diagnosed within the past 5 years and who had no recent hypoglycemic treatment were enrolled from 23 hospitals in China. All of the patients ...
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OBJECTIVE In the pancreatic beta-cell, ATP-sensitive K(+) (K(ATP)) channels couple metabolism with excitability and consist of Kir6.2 and SUR1 subunits encoded by KCNJ11 and ABCC8, respectively. Sulfonylureas, which inhibit the K(ATP) channel, are used to treat type 2 diabetes. Rare activating mutations cause neonatal diabetes, whereas the common variants, E23K in KCNJ11 and S1369A in ABCC8, ar...
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Maturity-onset diabetes of the young (MODY) is a heterogeneous group of diseases associated with gene mutations leading to dysfunction of pancreatic β-cells. Thirteen identified MODY variants differ from each other by the clinical course and treatment requirement. Currently, MODY subtypes 1-5 are best-studied, descriptions of the other forms are sporadic. This article reports a MODY12 clinical ...
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